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Discussion Starter · #1 ·
Wondering if anyone takes (or has experienced) a different levothyroxine dose during the week, like a higher or lower amount a couple of times a week or on alternating days? I'm wondering if it basically has the same effect as the average daily dose because of the longer half life - I assume 2-4 weeks afterwards it's not noticeable day to day that a different dose was taken?

I ask because I need to raise my free T4 very gradually, I'd like to see it happen over six months or so, allowing time to ensure I'm able to manage it and adjust liothyronine down a bit accordingly.

Thank you!
 

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I've been on alternating doses in the past to achieve something in the middle of the doses. Personally I find it's best to be on a steady dose if possible. And usually that can be achieved by splitting pills of different strengths. I used to split a 50 and an 88 to get 94 for awhile. I liked that better than alternating 88 and 100 each day. When I was alternating, it seemed like my body was going up and down also.

Currently I'm on 112 but I switched to Synthroid name brand and it seems to hit me different.

If you seem to be sensitive to dose changes like I was, I think it had to do with other aspects like nutrition and vitamin deficiencies. I had Iron issues and was deficient in Vitamin D (very common for us with hashimotos). Turning those items around seemed to help me process the pills. I also seem to have general gut issues. And addressing those issues through eliminating certain foods seems to impact my absorption of the pills also. I went through some real ups and downs with my tests which I think had to do with my gut issues.

It can take some time to figure out how to get this all under control. What are your labs currently.
 

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Yes I think alternating day to day works fine without noticing ups and downs. I alternate 75 mcg with half a 125 mcg.
 
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Discussion Starter · #4 ·
I've been on alternating doses in the past to achieve something in the middle of the doses. Personally I find it's best to be on a steady dose if possible. And usually that can be achieved by splitting pills of different strengths. I used to split a 50 and an 88 to get 94 for awhile. I liked that better than alternating 88 and 100 each day. When I was alternating, it seemed like my body was going up and down also.

Currently I'm on 112 but I switched to Synthroid name brand and it seems to hit me different.

If you seem to be sensitive to dose changes like I was, I think it had to do with other aspects like nutrition and vitamin deficiencies. I had Iron issues and was deficient in Vitamin D (very common for us with hashimotos). Turning those items around seemed to help me process the pills. I also seem to have general gut issues. And addressing those issues through eliminating certain foods seems to impact my absorption of the pills also. I went through some real ups and downs with my tests which I think had to do with my gut issues.

It can take some time to figure out how to get this all under control. What are your labs currently.
Thanks for the reply! I will get my labs and post, but essentially my levothyroxine was lowered when I started taking liothyronine due to reverse T3. That's been resolved for a while but the doctor I had been working with moved and changed his practice, now I'm trying to figure out how to raise my T4 and lower T3 smoothly. I figured if I did it VERY slowly that it might work.

Do you truly notice that you feel different day to day? Is it 2-4 weeks out from taking it, or right away?
 

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Discussion Starter · #5 ·
Yes I think alternating day to day works fine without noticing ups and downs. I alternate 75 mcg with half a 125 mcg.
Thank you! How long have you been doing this? I think from your signature you've had a partial thyroidectomy, correct? Not sure it would make any difference after a TT versus a partial, just trying to gather all the info. :)
 

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Thanks for the reply! I will get my labs and post, but essentially my levothyroxine was lowered when I started taking liothyronine due to reverse T3. That's been resolved for a while but the doctor I had been working with moved and changed his practice, now I'm trying to figure out how to raise my T4 and lower T3 smoothly. I figured if I did it VERY slowly that it might work.

Do you truly notice that you feel different day to day? Is it 2-4 weeks out from taking it, or right away?
I have to say it's pretty hard to judge in my case because I was having a lot of issues during that timeframe. But I personally felt it is better to try and get a consistent number when possible. I think I also had some absorption issues causing inconsistent levels. I'm very careful with taking mine, but my gut had issues in the past and eating better and avoiding certain foods seems to help.

What kind of RT3 issues were you having. I personally find RT3 is a bit tricky to gauge when on thyroid medication. It's a controversial subject as conventional doctors find it's not a useful test and some functional doctors think it's the most important. I personally think it's not too important on T4 only. On T3 or combination it could be useful to see if you are over-medicating. But using FT3 might be a better indicator of things (and FT4 of course).

I've been hesitating doing combination medicine because I worry about it being managed correctly or a situation like yours where a doctor moves away. Maybe that same doctor could do distance consulting for you. Seems like this is something where you don't need to be in person.
 

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Thank you! How long have you been doing this? I think from your signature you've had a partial thyroidectomy, correct? Not sure it would make any difference after a TT versus a partial, just trying to gather all the info. :)
 

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At least 2 years if not more. 62.5 a day was way too little for me and I def became hyper at 75 mcg/day. Yes I had a partial thyroidecyomy and I weigh about 215.
 
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